NIH—NATIONAL LIBRARY OF MEDICINENATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION
Ozone therapy: A clinical review.
Elvis AM, Ekta JS.J Nat Sci Biol Med. 2011 Jan;2(1):66-70. doi: 10.4103/0976-9668.82319.PMID: 22470237
Emerging roles of ozone in skin diseases.
PMID: 23717326
Chirumbolo S, Franzini M, Simonetti V, Valdenassi L, Ricevuti G, Bertossi D, Pandolfi S.J Med Virol. 2021 Jan 27. doi: 10.1002/jmv.26806. Online ahead of print.PMID: 33503267
Mehraban F, Seyedarabi A, Seraj Z, Ahmadian S, Poursasan N, Rayati S, Moosavi-Movahedi AA.Int J Biol Macromol. 2018 Nov;119:1276-1285. doi: 10.1016/j.ijbiomac.2018.08.028. Epub 2018 Aug 8.PMID: 30096397
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Estrogenic activity removal of 17beta-estradiol by ozonation and identification of by-products.
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Similarities and differences of hyperbaric oxygen and medical ozone applications.
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Ozone: a new therapeutic agent in vascular diseases.
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28;43(2):114-123. doi: 10.11817/j.issn.1672-7347.2018.02.002.PMID: 29559592
Validity of Oxygen-Ozone Therapy as Integrated Medication Form in Chronic Inflammatory Diseases.
Bocci V, Zanardia I, Valacchi G, Borrelli E, Travagli V. Cardiovasc Hematol Disord Drug Targets. 2015;15(2):127-38. doi: 10.2174/1871529×1502151209114642.PMID: 26126818 Review.
Inactivation of fungi associated with barley grain by gaseous ozone.
Allen B, Wu J, Doan H.J Environ Sci Health B. 2003 Sep;38(5):617-30. doi: 10.1081/PFC-120023519.PMID: 12929720
[Precise application of Traditional Chinese Medicine in minimally-invasive techniques].
Dong FH.Zhongguo Gu Shang. 2018 Jun 25;31(6):493-496. doi: 10.3969/j.issn.1003-0034.2018.06.001.PMID: 29945400 Chinese.
Anton syndrome during oxygen-ozone therapy.
Avcı S, Büyükcam F, Demir ÖF, Özkan S.Am J Emerg Med. 2015 Jun;33(6):856.e1-2. doi: 10.1016/j.ajem.2014.11.041. Epub 2014 Dec 2.PMID: 25511367
Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility.
Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA.Med Gas Res. 2017 Oct 17;7(3):212-219. doi: 10.4103/2045-9912.215752. eCollection 2017 Jul-Sep.PMID: 29152215
Personalizing the safe, appropriate and effective concentration(s) of ozone for a non-diabetic individual and four type II diabetic patients in autohemotherapy through blood hemoglobin analysis
Fouad Mehraban 1, Arefeh Seyedarabi 2, Shahin Ahmadian 1, Vahid Mirzaaghaei 3, Ali Akbar Moosavi-Movahedi 1
Affiliations expand
PMID: 31311548
PMCID: PMC6636166
DOI: 10.1186/s12967-019-1973-5
Abstract
Background: Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the currently used complementary therapies for diabetes is ozone therapy or autohemotherapy. The beneficial effects of ozone has been proven in many diseases such as diabetes, but the critical issue is the determination of the safe and effective concentration of ozone reacting with blood and in particular hemoglobin.
Methods: A number of spectroscopic techniques including intrinsic fluorescence, circular dichroism and UV-VIS spectroscopies were used as well as SDS-PAGE, Native-PAGE and dynamic light scattering to analyze the effect of ozonation on hemoglobin of a non-diabetic individual and four diabetic patients in order to find the appropriate concentration(s) of ozone for personalized autohemotherapy.
Results: In this study, we determined the personalized concentration(s) for a safe and effective ozonation of a non-diabetic individual and four diabetic type II patients, based on blood hemoglobin analysis.
Cited by 3 articles
Antimycotic Activity of Ozonized Oil in Liposome Eye Drops against Candida spp.Celenza G, Iorio R, Cracchiolo S, Petricca S, Costagliola C, Cinque B, Segatore B, Amicosante G, Bellio P. Transl Vis Sci Technol. 2020 Jul 2;9(8):4. doi: 10.1167/tvst.9.8.4. eCollection 2020 Jul.PMID: 32855851 .
Ozonated Oils as Antimicrobial Systems in Topical Applications. Their Characterization, Current Applications, and Advances in Improved Delivery Techniques.Ugazio E, Tullio V, Binello A, Tagliapietra S, Dosio F. Molecules. 2020 Jan 14;25(2):334. doi: 10.3390/molecules25020334.PMID: 31947580
The antibacterial effect of topical ozone on the treatment of MRSA skin infection.
Song M, Zeng Q, Xiang Y, Gao L, Huang J, Huang J, Wu K, Lu J.Mol Med Rep. 2018 Feb;17(2):2449-2455. doi: 10.3892/mmr.2017.8148. Epub 2017 Nov 24.PMID: 29207120 F
Effect of low-dose gaseous ozone on pathogenic bacteria
Belchor Fontes 1, Ana Maria Cattani Heimbecker, Glacus de Souza Brito, Silvia F Costa, Inneke M van der Heijden, Anna S Levin, Samir Rasslan
Affiliations expand
· PMID: 23249441
· PMCID: PMC3541223
· DOI: 10.1186/1471-2334-12-358
Abstract
Background: Treatment of chronically infected wounds is a challenge, and bacterial environmental contamination is a growing issue in infection control. Ozone may have a role in these situations. The objective of this study was to determine whether a low dose of gaseous ozone/oxygen mixture eliminates pathogenic bacteria cultivated in Petri dishes.
Methods: A pilot study with 6 bacterial strains was made using different concentrations of ozone in an ozone-oxygen mixture to determine a minimally effective dose that completely eliminated bacterial growth. The small and apparently bactericidal gaseous dose of 20 μg/mL ozone/oxygen (1:99) mixture, applied for 5 min under atmospheric pressure was selected. In the 2nd phase, eight bacterial strains with well characterized resistance patterns were evaluated in vitro using agar-blood in adapted Petri dishes (105 bacteria/dish). The cultures were divided into 3 groups: 1–ozone-oxygen gaseous mixture containing 20 μg of O(3)/mL for 5 min; 2–100% oxygen for 5 min; 3–baseline: no gas was used.
Results: The selected ozone dose was applied to the following eight strains: Escherichia coli, oxacillin-resistant Staphylococcus aureus, oxacillin-susceptible Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae, carbapenem-resistant Acinetobacter baumannii, Acinetobacter baumannii susceptible only to carbapenems, and Pseudomonas aeruginosa susceptible to imipenem and meropenem. All isolates were completely inhibited by the ozone-oxygen mixture while growth occurred in the other 2 groups.
Conclusion: A single topical application by nebulization of a low ozone dose completely inhibited the growth of all potentially pathogenic bacterial strains with known resistance to antimicrobial agents.
Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain
Nady Braidy 1, Morteza Izadi 2, Antoni Sureda 3, Nematollah Jonaidi-Jafari 2, Abdolali Banki 4, Seyed F Nabavi 5, Seyed M Nabavi 5
Affiliations expand
· PMID: 28594115
· DOI: 10.1002/jcp.26044
Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?
Sagai M, Bocci V.Med Gas Res. 2011 Dec 20;1:29. doi: 10.1186/2045-9912-1-29.PMID: 22185664 A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model.Wiegman CH, Li F, Clarke CJ, Jazrawi E, Kirkham P, Barnes PJ, Adcock IM, Chung KF. Clin Sci (Lond). 2014 Mar;126(6):425-40. doi: 10.1042/CS20130039.PMID: 24040961
The usefulness of ozone treatment in spinal pain.Bocci V, Borrelli E, Zanardi I, Travagli V.Drug Des Devel Ther. 2015 May 15;9:2677-85. doi: 10.2147/DDDT.S74518. eCollection 2015.PMID: 26028964
The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure.Galiè M, Covi V, Tabaracci G, Malatesta M.Int J Mol Sci. 2019 Aug 17;20(16):4009. doi: 10.3390/ijms20164009.PMID: 31426459
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Cited by 10 articles
Ozone Exposure Induces Metabolic Disorders and NAD+ Depletion Through PARP1 Activation in Spinal Cord Neurons.Ma S, Zhao X, Zhang C, Sun P, Li Y, Lin X, Sun T, Fu Z. Front Med (Lausanne). 2020 Dec 17;7:617321. doi: 10.3389/fmed.2020.617321. eCollection 2020.PMID: 33425964 .
Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury.Liu P, Chen J, Ma S, Zhang J, Zhou J. Int J Neuropsychopharmacol. 2021 Jan 20;24(1):64-76. doi: 10.1093/ijnp/pyaa076.PMID: 33000169
Bioactive Diarylheptanoids from Alpinia coriandriodora.
Cheng XL, Li HX, Chen J, Wu P, Xue JH, Zhou ZY, Xia NH, Wei XY.Nat Prod Bioprospect. 2021 Feb;11(1):63-72. doi: 10.1007/s13659-020-00264-y. Epub 2020 Sep 9.PMID: 32902805
Ozone: a natural bioactive molecule with antioxidant property as potential new strategy in aging and in neurodegenerative disorders.Scassellati C, Galoforo AC, Bonvicini C, Esposito C, Ricevuti G. Ageing Res Rev. 2020 Nov;63:101138. doi: 10.1016/j.arr.2020.101138. Epub 2020 Aug 15.PMID: 32810649 .
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The case for oxygen-ozonetherapy.
Bocci V.Br J Biomed Sci. 2007;64(1):44-9. doi: 10.1080/09674845.2007.11732755.PMID: 17444419 Review
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May oxygen-ozone therapy improves cardiovascular disorders?
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Extracorporeal blood oxygenation and ozonation (EBOO) in man. preliminary report.
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Intravesical ozone therapy for progressive radiation-induced hematuria.
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Anti-fungal potential of ozone against some dermatophytes.
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